Development, physicochemical evaluation, and in vivo permeation studies of topical formulations containing 0.1% tacrolimus

• Main Authors: Mariana Villas Bôas Vidal de Oliveira (Author), Priscila Elias Alves (Author), Jessica Teixeira (Author), Mariana Sato de Souza de Bustamante Monteiro (Author), Tailane Sant'Anna Moreira (Author), Eduardo Ricci Junior (Author), Elisabete Pereira dos Santos (Author), Ralph Santos-Oliveira (Author), Rita de Cássia Elias Estrela Marins (Author), Zaida Maria Faria de Freitas (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The objective of this paper was to develop and evaluate two semi-solid pharmaceutical forms containing 0.1% tacrolimus: cream (CRT01) and gel (GLT01). For the evaluation of physicochemical stability, at times 0, 30, 60 and 90 days, at 23°C and at 40°C, High Performance Liquid Chromatography...