Preparation, characterization, dissolution, and permeation of flibanserin − 2-HP-β-cyclodextrin inclusion complexes

• Main Authors: Adel F. Alghaith (Author), Gamal M. Mahrous (Author), Diaa Eldin Zidan (Author), Nabil A. Alhakamy (Author), Abdulmohsin J. Alamoudi (Author), Awwad A. Radwan (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flibanserin (FLB), an antiserotonin drug, is used to treat women with hypoactive sexual appetite disorder. FLB shows low bioavailability (~33%) probably due to its low water solubility. The current study investigated the impact of hydroxypropyl-β-cyclodextrin (HP-β-CD) and sodium lauryl sulfate (SLS...