Mechanisms of glabridin inhibition of integrin αIIbβ3 inside-out signals and NF-κB activation in human platelets

• Main Authors: Wei-Chieh Huang (Author), Thanasekaran Jayakumar (Author), Joen-Rong Sheu (Author), Chih-Wei Hsia (Author), Chih-Hsuan Hsia (Author), Ting-Lin Yen (Author), Chao-Chien Chang (Author)
• Format: Book
• Published: BMC, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Platelets play a crucial role in cardiovascular diseases (CVDs) and are activated by endogenous agonists like collagen. These agonists initiate signal transduction through specific platelet receptors, resulting in platelet aggregation. Glabridin, a prenylated isoflavonoid found i...