Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis

• Main Authors: Feixia Wang (Author), Zhanghao Li (Author), Li Chen (Author), Ting Yang (Author), Baoyu Liang (Author), Zili Zhang (Author), Jiangjuan Shao (Author), Xuefen Xu (Author), Guoping Yin (Author), Shijun Wang (Author), Hai Ding (Author), Feng Zhang (Author), Shizhong Zheng (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Senescence of activated hepatic stellate cells (aHSCs) is a stable growth arrest that is implicated in liver fibrosis regression. Senescent cells often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). But little is known about how alanine-serine-cysteine transporter t...