Combined Self-Nanoemulsifying and Solid Dispersion Systems Showed Enhanced Cinnarizine Release in Hypochlorhydria/Achlorhydria Dissolution Model

• Principais autores: Ahmad A. Shahba (Autor), Ahmad Y. Tashish (Autor), Fars K. Alanazi (Autor), Mohsin Kazi (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2021-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The study aims to design a novel combination of drug-free solid self-nanoemulsifying drug delivery systems (S-SNEDDS) + solid dispersion (SD) to enhance cinnarizine (CN) dissolution at high pH environment caused by hypochlorhydria/achlorhydria. Drug-loaded and drug-free liquid SNEDDS were solidified...