Catastrophic neurologic manifestations of a common immunodeficiency syndrome

• Main Authors: Nitika Agrawal (Author), Gnanam Ram (Author), Shiv Kumar (Author), Bidisha Banarjee (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 2349-6592; 2455-7099; 10.21304/2015.0202.00072
• Keywords: hiv children; leukoencephalopathy; neurological manifestations; progressive; Pediatrics; RJ1-570
• Source: Journal of Pediatric Critical Care, Vol 2, Iss 2, Pp 75-77 (2015)

A high index of suspicion is needed in pediatric patients with neurological symptoms being the sole presenting manifestation, to diagnose infection with the Human Immunodeficiency Vnus (HIV). This is a write up of two such cases who were admitted to the pediatric intensive care unit with neurological manifestations. A 6 year old previously healthy child, who initially presented with intermittent drowsiness and fluctuation in blood pressine, later during hospital stay, developed progressive motor, cognitive, visual and language difficulties. Investigations revealed the child to be HIV positive and magnetic resonance imaging (MRI) findings were consistent with progressive multifocal leucoencephalopathy. A12 yr old child had stroke initially (for which extensive work up had been done) and later, after 8 months presented with the same complaints along with severe pneumonia .He succumbed to severe opportunistic infections. That he was HIV positive, had not been detected during the first admission as left sided weakness was the only presenting manifestation.