Spider Venom Peptide Pn3a Inhibition of Primary Afferent High Voltage-Activated Calcium Channels

• Hauptverfasser: Jeffrey R. McArthur (Verfasst von), Nehan R. Munasinghe (Verfasst von), Rocio K. Finol-Urdaneta (Verfasst von), David J. Adams (Verfasst von), Macdonald J. Christie (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Schlagworte: article
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Despite potently inhibiting the nociceptive voltage-gated sodium (Nav) channel, Nav1.7, µ-theraphotoxin Pn3a is antinociceptive only upon co-administration with sub-therapeutic opioid agonists, or by itself at doses >3,000-fold greater than its Nav1.7 IC50 by a yet undefined mechanism. Nav channe...