Recombinant botulinum neurotoxin serotype A1 in vivo characterization

• Main Authors: Cindy Périer (Author), Vincent Martin (Author), Sylvie Cornet (Author), Christine Favre‐Guilmard (Author), Marie‐Noelle Rocher (Author), Julien Bindler (Author), Stéphanie Wagner (Author), Emile Andriambeloson (Author), Brian B. Rudkin (Author), Rudy Marty (Author), Alban Vignaud (Author), Matthew Beard (Author), Stephane Lezmi (Author), Mikhail Kalinichev (Author)
• Format: Book
• Published: Wiley, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Clinically used botulinum neurotoxins (BoNTs) are natural products of Clostridium botulinum. A novel, recombinant BoNT type A1 (rBoNT/A1; IPN10260) has been synthesized using the native amino acid sequence expressed in Escherichia coli and has previously been characterized in vitro and ex v...