Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy

• Main Authors: Xiaojun Song (Author), Jianming Lv (Author), Zhiqin Cao (Author), Huiyun Huang (Author), Guodong Chen (Author), Takayoshi Awakawa (Author), Dan Hu (Author), Hao Gao (Author), Ikuro Abe (Author), Xinsheng Yao (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fusidane-type antibiotics, represented by helvolic acid, fusidic acid and cephalosporin P1, are fungi-derived antimicrobials with little cross-resistance to commonly used antibiotics. Generation of new fusidane-type derivatives is therefore of great value, but this is hindered by available approache...