A mechanistic modeling platform of SGLT2 inhibition: Implications for type 1 diabetes

• Autori principali: Victor Sokolov (Autore), Tatiana Yakovleva (Autore), Leonid Stolbov (Autore), Robert C. Penland (Autore), David Boulton (Autore), Joanna Parkinson (Autore), Weifeng Tang (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2023-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Type 1 diabetes mellitus (T1DM) is an autoimmune disease characterized by abnormally high blood glucose concentrations due to dysfunction of the insulin‐producing beta‐cells in the pancreas. Dapagliflozin, an inhibitor of renal glucose reabsorption, has the potential to improve often subopt...