Identification of Autophagy as a Functional Target Suitable for the Pharmacological Treatment of Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN) In Vitro

• Main Authors: Enrica Zanuttigh (Author), Kevork Derderian (Author), Miriam A. Güra (Author), Arie Geerlof (Author), Ivano Di Meo (Author), Chiara Cavestro (Author), Stefan Hempfling (Author), Stephanie Ortiz-Collazos (Author), Mario Mauthe (Author), Tomasz Kmieć (Author), Eugenia Cammarota (Author), Maria Carla Panzeri (Author), Thomas Klopstock (Author), Michael Sattler (Author), Juliane Winkelmann (Author), Ana C. Messias (Author), Arcangela Iuso (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial membrane protein-associated neurodegeneration (MPAN) is a relentlessly progressive neurodegenerative disorder caused by mutations in the <i>C19orf12</i> gene. C19orf12 has been implicated in playing a role in lipid metabolism, mitochondrial function, and autophagy, however,...