Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant

• প্রধান লেখক: Lucie Yammine (লেখক), Belén Picatoste (লেখক), Nazish Abdullah (লেখক), Rosemary A. Leahey (লেখক), Emma F. Johnson (লেখক), Nicolás Gómez-Banoy (লেখক), Carolina Rosselot (লেখক), Jennifer Wen (লেখক), Tahmina Hossain (লেখক), Marcus D. Goncalves (লেখক), James C. Lo (লেখক), Adolfo Garcia-Ocaña (লেখক), Timothy E. McGraw (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2023-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Objective: Glucose-dependent insulinotropic polypeptide (GIP) has a role in controlling postprandial metabolic tone. In humans, a GIP receptor (GIPR) variant (Q354, rs1800437) is associated with a lower body mass index (BMI) and increased risk for Type 2 Diabetes. To better understand the impacts of...