Spatiotemporal regulation of GIPR signaling impacts glucose homeostasis as revealed in studies of a common GIPR variant

• Main Authors: Lucie Yammine (Author), Belén Picatoste (Author), Nazish Abdullah (Author), Rosemary A. Leahey (Author), Emma F. Johnson (Author), Nicolás Gómez-Banoy (Author), Carolina Rosselot (Author), Jennifer Wen (Author), Tahmina Hossain (Author), Marcus D. Goncalves (Author), James C. Lo (Author), Adolfo Garcia-Ocaña (Author), Timothy E. McGraw (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glucose-dependent insulinotropic polypeptide (GIP) has a role in controlling postprandial metabolic tone. In humans, a GIP receptor (GIPR) variant (Q354, rs1800437) is associated with a lower body mass index (BMI) and increased risk for Type 2 Diabetes. To better understand the impacts of...