Vulnerability of Triple-Negative Breast Cancer to Saponin Formosanin C-Induced Ferroptosis

• Main Authors: Hsin-Chih Chen (Author), Han-Hsuan Tang (Author), Wei-Hsiang Hsu (Author), Shan-Ying Wu (Author), Wen-Hsing Cheng (Author), Bao-Yuan Wang (Author), Chun-Li Su (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeting ferritin via autophagy (ferritinophagy) to induce ferroptosis, an iron- and reactive oxygen species (ROS)-dependent cell death, provides novel strategies for cancer therapy. Using a ferroptosis-specific inhibitor and iron chelator, the vulnerability of triple-negative breast cancer (TNBC)...