Activation of the Nkx2.5-Calr-p53 signaling pathway by hyperglycemia induces cardiac remodeling and dysfunction in adult zebrafish

• Main Authors: Yanyi Sun (Author), Qiuyun Wang (Author), Yuehua Fang (Author), Chunfang Wu (Author), Guoping Lu (Author), Zhenyue Chen (Author)
• Format: Book
• Published: The Company of Biologists, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperglycemia is an independent risk factor for diabetic cardiomyopathy in humans; however, the underlying mechanisms have not been thoroughly elucidated. Zebrafish (Danio rerio) was used in this study as a novel vertebrate model to explore the signaling pathways of human adult cardiomyopathy. Hyper...