The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway.

• Asıl Yazarlar: Annarita Fiorillo (Yazar), Gianni Colotti (Yazar), Alberto Boffi (Yazar), Paola Baiocco (Yazar), Andrea Ilari (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Leishmaniasis is a neglected disease caused by Leishmania, an intracellular protozoan parasite which possesses a unique thiol metabolism based on trypanothione. Trypanothione is used as a source of electrons by the tryparedoxin/tryparedoxin peroxidase system (TXN/TXNPx) to reduce the hydroperoxides...