The crystal structures of the tryparedoxin-tryparedoxin peroxidase couple unveil the structural determinants of Leishmania detoxification pathway.

• Váldodahkkit: Annarita Fiorillo (Dahkki), Gianni Colotti (Dahkki), Alberto Boffi (Dahkki), Paola Baiocco (Dahkki), Andrea Ilari (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Leishmaniasis is a neglected disease caused by Leishmania, an intracellular protozoan parasite which possesses a unique thiol metabolism based on trypanothione. Trypanothione is used as a source of electrons by the tryparedoxin/tryparedoxin peroxidase system (TXN/TXNPx) to reduce the hydroperoxides...