Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers

• Main Authors: Guzmán Leda (Author), Depix María (Author), Salinas Ana (Author), Roldán Rosa (Author), Aguayo Francisco (Author), Silva Alejandra (Author), Vinet Raul (Author)
• Format: Book
• Published: BMC, 2012-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Chronic obstructive pulmonary disease (COPD) is a disorder associated to cigarette smoke and lung cancer (LC). Since epigenetic changes in oncogenes and tumor suppressor genes (TSGs) are clearly important in the development of LC. In...