Induction of IL-12 Production in Human Peripheral Monocytes by Trypanosoma cruzi Is Mediated by Glycosylphosphatidylinositol-Anchored Mucin-Like Glycoproteins and Potentiated by IFN-γ and CD40-CD40L Interactions

• Main Authors: Lúcia Cristina Jamli Abel (Author), Ludmila Rodrigues Pinto Ferreira (Author), Isabela Cunha Navarro (Author), Monique Andrade Baron (Author), Jorge Kalil (Author), Ricardo Tostes Gazzinelli (Author), Luiz Vicente Rizzo (Author), Edecio Cunha-Neto (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is characterized by immunopathology driven by IFN-γ secreting Th1-like T cells. T. cruzi has a thick coat of mucin-like glycoproteins covering its surface, which plays an important role in parasite invasion and host immun...