Heterotypic mouse models of canine osteosarcoma recapitulate tumor heterogeneity and biological behavior

• Main Authors: Milcah C. Scott (Author), Hirotaka Tomiyasu (Author), John R. Garbe (Author), Ingrid Cornax (Author), Clarissa Amaya (Author), M. Gerard O'Sullivan (Author), Subbaya Subramanian (Author), Brad A. Bryan (Author), Jaime F. Modiano (Author)
• Format: Book
• Published: The Company of Biologists, 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteosarcoma (OS) is a heterogeneous and rare disease with a disproportionate impact because it mainly affects children and adolescents. Lamentably, more than half of patients with OS succumb to metastatic disease. Clarification of the etiology of the disease, development of better strategies to man...