Rational formulation engineering of fraxinellone utilizing 6-O-α-D-maltosyl-β-cyclodextrin for enhanced oral bioavailability and hepatic fibrosis therapy

• Автори: Jianbo Li (Автор), Tiange Feng (Автор), Weijing Yang (Автор), Yaru Xu (Автор), Shuaishuai Wang (Автор), Huijie Cai (Автор), Zhilei Liu (Автор), Hong Qiang (Автор), Jinjie Zhang (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Although Fraxinellone (Frax) isolated from Dictamnus albus L. possessed excellent anti-hepatic fibrosis activity, oral administration of Frax suffered from the inefficient therapeutic outcome in vivo due to negligible oral absorption. At present, the oral formulation of Frax is rarely exploited. For...