Rational formulation engineering of fraxinellone utilizing 6-O-α-D-maltosyl-β-cyclodextrin for enhanced oral bioavailability and hepatic fibrosis therapy

Although Fraxinellone (Frax) isolated from Dictamnus albus L. possessed excellent anti-hepatic fibrosis activity, oral administration of Frax suffered from the inefficient therapeutic outcome in vivo due to negligible oral absorption. At present, the oral formulation of Frax is rarely exploited. For...

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Main Authors: Jianbo Li (Author), Tiange Feng (Author), Weijing Yang (Author), Yaru Xu (Author), Shuaishuai Wang (Author), Huijie Cai (Author), Zhilei Liu (Author), Hong Qiang (Author), Jinjie Zhang (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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