Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors

Aim: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma. Several classes of chemotypes have been identified, which interfere with the enzyme activity of KDAC8. These compound...

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Main Authors: Markus Schweipert (Author), Anuja Amurthavasan (Author), Franz-Josef (Author)
Format: Book
Published: Open Exploration Publishing Inc., 2023-06-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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