Transport and metabolism at blood-brain interfaces and in neural cells: relevance to bilirubin-induced encephalopathy

• Main Authors: Silvia eGazzin (Author), Nathalie eStrazielle (Author), Claudio eTiribelli (Author), Jean-François e (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bilirubin, the end-product of heme catabolism, circulates in non pathological plasma mostly as a protein-bound species. When bilirubin concentration builds up, the free fraction of the molecule increases. Unbound bilirubin then diffuses across blood-brain interfaces into the brain, where it accumula...