Formulation of Chitosan-Coated Brigatinib Nanospanlastics: Optimization, Characterization, Stability Assessment and In-Vitro Cytotoxicity Activity against H-1975 Cell Lines

• Autores principales: Randa Mohammed Zaki (Autor), Munerah M. Alfadhel (Autor), Saad M. Alshahrani (Autor), Ahmed Alsaqr (Autor), Layla A. Al-Kharashi (Autor), Md Khalid Anwer (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2022-03-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The purpose of the current study was to develop Brigatinib (BGT)-loaded nanospanlastics (BGT-loaded NSPs) (S1-S13) containing Span 60 with different edge activators (Tween 80 and Pluronic F127) and optimized based on the vesicle size, zeta potential (ZP), and percent entrapment efficiency (%EE) usin...