Formulation of Chitosan-Coated Brigatinib Nanospanlastics: Optimization, Characterization, Stability Assessment and In-Vitro Cytotoxicity Activity against H-1975 Cell Lines

Formulation of Chitosan-Coated Brigatinib Nanospanlastics: Optimization, Characterization, Stability Assessment and In-Vitro Cytotoxicity Activity against H-1975 Cell Lines

The purpose of the current study was to develop Brigatinib (BGT)-loaded nanospanlastics (BGT-loaded NSPs) (S1-S13) containing Span 60 with different edge activators (Tween 80 and Pluronic F127) and optimized based on the vesicle size, zeta potential (ZP), and percent entrapment efficiency (%EE) usin...

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Main Authors: Randa Mohammed Zaki (Author), Munerah M. Alfadhel (Author), Saad M. Alshahrani (Author), Ahmed Alsaqr (Author), Layla A. Al-Kharashi (Author), Md Khalid Anwer (Author)
Format: Book
Published: MDPI AG, 2022-03-01T00:00:00Z.
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