Metformin Protects against Radiation-Induced Pneumonitis and Fibrosis and Attenuates Upregulation of Dual Oxidase Genes Expression

• Main Authors: Rasoul Azmoonfar (Author), Peyman Amini (Author), Hana Saffar (Author), Saeed Rezapoor (Author), Elahe Motevaseli (Author), Mohsen Cheki (Author), Rasoul Yahyapour (Author), Bagher farhood (Author), Farzad Nouruzi (Author), Ehsan Khodamoradi (Author), Dheyauldeen Shabeeb (Author), Ahmed Eleojo Musa (Author), Masoud Najafi (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Lung tissue is one of the most sensitive organs to ionizing radiation (IR). Early and late side effects of exposure to IR can limit the radiation doses delivered to tumors that are within or adjacent to this organ. Pneumonitis and fibrosis are the main side effects of radiotherapy for this...