Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2.

• Glavni autori: Mark S Pearson (Autor), Darren A Pickering (Autor), Henry J McSorley (Autor), Jeffrey M Bethony (Autor), Leon Tribolet (Autor), Annette M Dougall (Autor), Peter J Hotez (Autor), Alex Loukas (Autor)
• Format: Knjiga
• Izdano: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

The large extracellular loop of the Schistosoma mansoni tetraspanin, Sm-TSP-2, when fused to a thioredoxin partner and formulated with Freund's adjuvants, has been shown to be an efficacious vaccine against murine schistosomiasis. Moreover, Sm-TSP-2 is uniquely recognised by IgG(1) and IgG(3) f...