Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2.

• Main Authors: Mark S Pearson (Author), Darren A Pickering (Author), Henry J McSorley (Author), Jeffrey M Bethony (Author), Leon Tribolet (Author), Annette M Dougall (Author), Peter J Hotez (Author), Alex Loukas (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The large extracellular loop of the Schistosoma mansoni tetraspanin, Sm-TSP-2, when fused to a thioredoxin partner and formulated with Freund's adjuvants, has been shown to be an efficacious vaccine against murine schistosomiasis. Moreover, Sm-TSP-2 is uniquely recognised by IgG(1) and IgG(3) f...