Development, stability and in vitro delivery profile of new loratadine-loaded nanoparticles

• Main Authors: Jesus Rafael Rodriguez Amado (Author), Ariadna Lafourcade Prada (Author), Jonatas Lobato Duarte (Author), Hady Keita (Author), Heitor Rivero da Silva (Author), Adriana Maciel Ferreira (Author), Edgar Hernandez Sosa (Author), Jose Carlos Tavares Carvalho (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Loratadine is used as antihistaminic without side effects in nervous systems. This drug is a weak base and it is absorbed from the intestine. The nitrogen of the pyridine ring is protonated in the stomach affecting the oral bioavailability. The aim of this paper was obtaining, characterize...