Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll® Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico, In Vitro, and Human Biomonitoring Data

• Huvudupphovsmän: Kevin McNally (Författare, medförfattare), Craig Sams (Författare, medförfattare), George Loizou (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: Frontiers Media S.A., 2019-11-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

A physiologically based pharmacokinetic model for Hexamoll® diisononyl-cyclohexane-1, 2-dicarboxylate was developed to interpret the biokinetics in humans after single oral doses. The model was parameterized with in vitro and in silico derived parameters and uncertainty and sensitivity analysis was...