Roxadustat (FG-4592) Facilitates Recovery From Renal Damage by Ameliorating Mitochondrial Dysfunction Induced by Folic Acid

• Main Authors: Xue Li (Author), Bo Jiang (Author), Yu Zou (Author), Jie Zhang (Author), Yuan-Yuan Fu (Author), Xiao-Yue Zhai (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Fag: article
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Incomplete recovery from acute kidney injury induced by folic acid is a major risk factor for progression to chronic kidney disease. Mitochondrial dysfunction has been considered a crucial contributor to maladaptive repair in acute kidney injury. Treatment with FG-4592, an inhibitor of hypoxia induc...