Selective Inhibition of the Immunoproteasome β5i Prevents PTEN Degradation and Attenuates Cardiac Hypertrophy

• Main Authors: Xin Xie (Author), Hong-Xia Wang (Author), Nan Li (Author), Ya-Wen Deng (Author), Hai-Lian Bi (Author), Yun-Long Zhang (Author), Yun-Long Xia (Author), Hui-Hua Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiac hypertrophy without appropriate treatment eventually progresses to heart failure. Our recent data demonstrated that the immunoproteasome subunit β5i promotes cardiac hypertrophy. However, whether β5i is a promising therapeutic target for treating hypertrophic remodeling remains unknown. Here...