Enhancement of Heme-Oxygenase 1 in the Injured Peripheral Nerve Following Sulforaphane Administration Fosters Regeneration via Proliferation and Maintenance of Repair Schwann Cells

• Main Authors: Fabian Szepanowski (Author), Jaqueline Zipfel (Author), Rebecca D. Szepanowski (Author), Bianca Eggert (Author), Nail-Mert Güner (Author), Leon-Phillip Szepanowski (Author), Christoph Kleinschnitz (Author), Anne K. Mausberg (Author), Mark Stettner (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2024-08-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Nuclear erythroid 2-related factor 2 (Nrf2) and its downstream effector heme oxygenase 1 (HO-1) are commonly activated in response to cellular stresses. The elevated expression of HO-1 has been associated with markedly accelerated peripheral nerve regeneration. This study aimed to evaluate the impac...