The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System

• Main Authors: Dionysios V. Chartoumpekis (Author), Panos G. Ziros (Author), Ilias Georgakopoulos-Soares (Author), Adam A. T. Smith (Author), Ana Claudia Marques (Author), Mark Ibberson (Author), Peter A. Kopp (Author), Ioannis Habeos (Author), Ioannis P. Trougakos (Author), Nicholas K. H. Khoo (Author), Gerasimos P. Sykiotis (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Thyroid follicular cells have physiologically high levels of reactive oxygen species because oxidation of iodide is essential for the iodination of thyroglobulin (Tg) during thyroid hormone synthesis. Thyroid follicles (the functional units of the thyroid) also utilize incompletely under...