Ageing contributes to phenotype transition in a mouse model of periodic paralysis

• Main Authors: Karen J. Suetterlin (Author), S. Veronica Tan (Author), Roope Mannikko (Author), Rahul Phadke (Author), Michael Orford (Author), Simon Eaton (Author), Avan A. Sayer (Author), Miranda D. Grounds (Author), Emma Matthews (Author), Linda Greensmith (Author), Michael G. Hanna (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Periodic paralysis (PP) is a rare genetic disorder in which ion channel mutation causes episodic paralysis in association with hyper‐ or hypokalaemia. An unexplained but consistent feature of PP is that a phenotype transition occurs around the age of 40, in which the severity of...