Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity

Cytochrome P450 3A (CYP3A) subfamily enzymes are involved in the metabolism of 40% of drugs in clinical use. Twin studies have indicated that 66% of the variability in CYP3A4 activity is hereditary. Yet, the complexity of the CYP3A locus and the lack of distinct drug metabolizer phenotypes has limit...

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Bibliografski detalji
Glavni autori: Qinglian Zhai (Autor), Maaike van der Lee (Autor), Teun van Gelder (Autor), Jesse J. Swen (Autor)
Format: Knjiga
Izdano: Frontiers Media S.A., 2022-06-01T00:00:00Z.
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