Why We Need to Take a Closer Look at Genetic Contributions to CYP3A Activity

Cytochrome P450 3A (CYP3A) subfamily enzymes are involved in the metabolism of 40% of drugs in clinical use. Twin studies have indicated that 66% of the variability in CYP3A4 activity is hereditary. Yet, the complexity of the CYP3A locus and the lack of distinct drug metabolizer phenotypes has limit...

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Autori principali: Qinglian Zhai (Autore), Maaike van der Lee (Autore), Teun van Gelder (Autore), Jesse J. Swen (Autore)
Natura: Libro
Pubblicazione: Frontiers Media S.A., 2022-06-01T00:00:00Z.
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