Single-shot AAV-vectored vaccine against SARS-CoV-2 with fast and long-lasting immunity

• Main Authors: Fuhua Wu (Author), Shuang Luo (Author), Yongshun Zhang (Author), Yangsen Ou (Author), Hairui Wang (Author), Zhaofei Guo (Author), Chunting He (Author), Shuting Bai (Author), Penghui He (Author), Min Jiang (Author), Xiaoyan Chen (Author), Guangsheng Du (Author), Xun Sun (Author)
• Format: Book
• Published: Elsevier, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Due to the insufficient long-term protection and significant efficacy reduction to new variants of current COVID-19 vaccines, the epidemic prevention and control are still challenging. Here, we employ a capsid and antigen structure engineering (CASE) strategy to manufacture an adeno-associated viral...