Drug reformulation for a neglected disease. The NANOHAT project to develop a safer more effective sleeping sickness drug.

• Main Authors: Lisa Sanderson (Author), Marcelo da Silva (Author), Gayathri N Sekhar (Author), Rachel C Brown (Author), Hollie Burrell-Saward (Author), Mehmet Fidanboylu (Author), Bo Liu (Author), Lea Ann Dailey (Author), Cécile A Dreiss (Author), Chris Lorenz (Author), Mark Christie (Author), Shanta J Persaud (Author), Vanessa Yardley (Author), Simon L Croft (Author), Margarita Valero (Author), Sarah A Thomas (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Human African trypanosomiasis (HAT or sleeping sickness) is caused by the parasite Trypanosoma brucei sspp. The disease has two stages, a haemolymphatic stage after the bite of an infected tsetse fly, followed by a central nervous system stage where the parasite penetr...