Fluorine-18 Labeled Urea-Based Ligands Targeting Prostate-Specific Membrane Antigen (PSMA) with Increased Tumor and Decreased Renal Uptake

• Main Authors: Falguni Basuli (Author), Tim E. Phelps (Author), Xiang Zhang (Author), Carolyn C. Woodroofe (Author), Jyoti Roy (Author), Peter L. Choyke (Author), Rolf E. Swenson (Author), Elaine M. Jagoda (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High expression of prostate-specific membrane antigen (PSMA) in prostate cancers prompted the development of the PSMA-targeted PET-imaging agent [¹⁸F]DCFPyL, which was recently approved by the FDA. Fluorine-18-labeled Lys-Urea-Glu-based oxime derivatives of [<sup>18</...