Smuggling on the Nanoscale-Fusogenic Liposomes Enable Efficient RNA-Transfer with Negligible Immune Response In Vitro and In Vivo

• Main Authors: Marco Hoffmann (Author), Sven Gerlach (Author), Masanari Takamiya (Author), Samar Tarazi (Author), Nils Hersch (Author), Agnes Csiszár (Author), Ronald Springer (Author), Georg Dreissen (Author), Hanno Scharr (Author), Sepand Rastegar (Author), Tanja Beil (Author), Uwe Strähle (Author), Rudolf Merkel (Author), Bernd Hoffmann (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The efficient and biocompatible transfer of nucleic acids into mammalian cells for research applications or medical purposes is a long-standing, challenging task. Viral transduction is the most efficient transfer system, but often entails high safety levels for research and potential health impairme...