Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats

• Главные авторы: Hany H. Arab (Автор), Ahmed H. Eid (Автор), Rania Yahia (Автор), Shuruq E. Alsufyani (Автор), Ahmed M. Ashour (Автор), Azza A. K. El-Sheikh (Автор), Hany W. Darwish (Автор), Muhammed A. Saad (Автор), Muhammad Y. Al-Shorbagy (Автор), Marwa A. Masoud (Автор)
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• Опубликовано: MDPI AG, 2023-08-01T00:00:00Z.
• Предметы: article
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Cadmium is an environmental toxicant that instigates cognitive deficits with excessive glutamate excitatory neuroactivity in the brain. Topiramate, a glutamate receptor antagonist, has displayed favorable neuroprotection against epilepsy, cerebral ischemia, and Huntington's disease; however, it...