Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats

• Main Authors: Hany H. Arab (Author), Ahmed H. Eid (Author), Rania Yahia (Author), Shuruq E. Alsufyani (Author), Ahmed M. Ashour (Author), Azza A. K. El-Sheikh (Author), Hany W. Darwish (Author), Muhammed A. Saad (Author), Muhammad Y. Al-Shorbagy (Author), Marwa A. Masoud (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cadmium is an environmental toxicant that instigates cognitive deficits with excessive glutamate excitatory neuroactivity in the brain. Topiramate, a glutamate receptor antagonist, has displayed favorable neuroprotection against epilepsy, cerebral ischemia, and Huntington's disease; however, it...