Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats

• मुख्य लेखकों: Hany H. Arab (लेखक), Ahmed H. Eid (लेखक), Rania Yahia (लेखक), Shuruq E. Alsufyani (लेखक), Ahmed M. Ashour (लेखक), Azza A. K. El-Sheikh (लेखक), Hany W. Darwish (लेखक), Muhammed A. Saad (लेखक), Muhammad Y. Al-Shorbagy (लेखक), Marwa A. Masoud (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Cadmium is an environmental toxicant that instigates cognitive deficits with excessive glutamate excitatory neuroactivity in the brain. Topiramate, a glutamate receptor antagonist, has displayed favorable neuroprotection against epilepsy, cerebral ischemia, and Huntington's disease; however, it...