Imatinib treatment causes substantial transcriptional changes in adult Schistosoma mansoni in vitro exhibiting pleiotropic effects.

• Main Authors: Christin Buro (Author), Svenja Beckmann (Author), Katia C Oliveira (Author), Colette Dissous (Author), Katia Cailliau (Author), Richard J Marhöfer (Author), Paul M Selzer (Author), Sergio Verjovski-Almeida (Author), Christoph G Grevelding (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schistosome parasites cause schistosomiasis, one of the most important infectious diseases worldwide. For decades Praziquantel (PZQ) is the only drug widely used for controlling schistosomiasis. The absence of a vaccine and fear of PZQ resistance have motivated the search for alternatives. Studies o...