Role for μ-opioid receptor in antidepressant effects of δ-opioid receptor agonist KNT-127

• Main Authors: Yuki Moriya (Author), Yoshiyuki Kasahara (Author), Masafumi Shimada (Author), Yasufumi Sakakibara (Author), Hideaki Fujii (Author), Hiroshi Nagase (Author), Soichiro Ide (Author), Kazutaka Ikeda (Author), F. Scott Hall (Author), George R. Uhl (Author), Ichiro Sora (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previous pharmacological data have shown the possible existence of functional interactions between μ- (MOP), κ- (KOP), and δ-opioid receptors (DOP) in pain and mood disorders. We previously reported that MOP knockout (KO) mice exhibit a lower stress response compared with wildtype (WT) mice. Moreove...