Investigating the Mechanism of Action of Diketopiperazines Inhibitors of the Burkholderia cenocepacia Quorum Sensing Synthase CepI: A Site-Directed Mutagenesis Study

• Main Authors: Silvia Buroni (Author), Viola C. Scoffone (Author), Marco Fumagalli (Author), Vadim Makarov (Author), Maddalena Cagnone (Author), Gabriele Trespidi (Author), Edda De Rossi (Author), Federico Forneris (Author), Giovanna Riccardi (Author), Laurent R. Chiarelli (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Quorum sensing (QS) is a bacterial intercellular communication process which controls the production of major virulence factors, such as proteases, siderophores, and toxins, as well as biofilm formation. Since the inhibition of this pathway reduces bacterial virulence, QS is considered a valuable ca...