Nanoparticles containing constrained phospholipids deliver mRNA to liver immune cells in vivo without targeting ligands

• Main Authors: Zubao Gan (Author), Melissa P. Lokugamage (Author), Marine Z. C. Hatit (Author), David Loughrey (Author), Kalina Paunovska (Author), Manaka Sato (Author), Ana Cristian (Author), James E. Dahlman (Author)
• Format: Book
• Published: Wiley, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Once inside the cytoplasm of a cell, mRNA can be used to treat disease by upregulating the expression of any gene. Lipid nanoparticles (LNPs) can deliver mRNA to hepatocytes in humans, yet systemic non‐hepatocyte delivery at clinical doses remains difficult. We noted that LNPs have historic...