Formulation and Characterization of Solid Lipid Nanoparticles Loading RF22-c, a Potent and Selective 5-LO Inhibitor, in a Monocrotaline-Induced Model of Pulmonary Hypertension

• Main Authors: Angela Liparulo (Author), Renata Esposito (Author), Debora Santonocito (Author), Alejandra Muñoz-Ramírez (Author), Giuseppe Spaziano (Author), Ferdinando Bruno (Author), Jianbo Xiao (Author), Carmelo Puglia (Author), Rosanna Filosa (Author), Liberato Berrino (Author), Bruno D'Agostino (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary arterial hypertension (PAH) is a rare but fatal disease characterized by persistent elevated blood pressure in the pulmonary circulation, due to increased resistance to blood flow, through the lungs. Advances in the understanding of the pathobiology of PAH clarify the role of leukotrienes...