The sensitivity of murine spermiogenesis to miglustat is a quantitative trait: a pharmacogenetic study

• Main Authors: Boomkamp Stephanie (Author), Gottwald Ulrich (Author), Leifke Eckhard (Author), Fritsch Martin (Author), Voigtmann Ulrike (Author), Walden Charlotte M (Author), Bone Wilhelm (Author), Platt Frances M (Author), van der Spoel Aarnoud C (Author)
• Format: Bog
• Udgivet: BMC, 2007-01-01T00:00:00Z.
• Fag: article
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<p>Abstract</p> <p>Background</p> <p>A major event in the post-meiotic development of male germ cells is the formation of the acrosome. This process can be perturbed in C57BL/6 mice by administration of the small molecule miglustat (N-butyldeoxynojirimycin, NB-DNJ). The...