Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids

• मुख्य लेखकों: Limei Li (लेखक), Qingce Zang (लेखक), Xinzhu Li (लेखक), Ying Zhu (लेखक), Shanjing Wen (लेखक), Jiuming He (लेखक), Ruiping Zhang (लेखक), Zeper Abliz (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Three-dimensional (3D) cell spheroid models combined with mass spectrometry imaging (MSI) enables innovative investigation of in vivo-like biological processes under different physiological and pathological conditions. Herein, airflow-assisted desorption electrospray ionization-MSI (AFADESI-MSI) was...