A fusion-inhibiting peptide against Rift Valley fever virus inhibits multiple, diverse viruses.

• Main Authors: Jeffrey W Koehler (Author), Jeffrey M Smith (Author), Daniel R Ripoll (Author), Kristin W Spik (Author), Shannon L Taylor (Author), Catherine V Badger (Author), Rebecca J Grant (Author), Monica M Ogg (Author), Anders Wallqvist (Author), Mary C Guttieri (Author), Robert F Garry (Author), Connie S Schmaljohn (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

For enveloped viruses, fusion of the viral envelope with a cellular membrane is critical for a productive infection to occur. This fusion process is mediated by at least three classes of fusion proteins (Class I, II, and III) based on the protein sequence and structure. For Rift Valley fever virus (...