Inhibition of Activin/Myostatin signalling induces skeletal muscle hypertrophy but impairs mouse testicular development

• Main Authors: Danielle Vaughan (Author), Olli Ritvos (Author), Robert Mitchell (Author), Oliver Kretz (Author), Maciej Lalowski (Author), Helge Amthor (Author), David Chambers (Author), Antonios Matsakas (Author), Arja Pasternack (Author), Henry Collins-Hooper (Author), Randy Ballesteros (Author), Tobias B. Huber (Author), Bernd Denecke (Author), Darius Widera (Author), Abir Mukherjee (Author), Ketan Patel (Author)
• Format: Book
• Published: PAGEPress Publications, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Numerous approaches are being developed to promote post-natal muscle growth based on attenuating Myostatin/Activin signalling for clinical uses such as the treatment neuromuscular diseases, cancer cachexia and sarcopenia. However there have been concerns about the effects of inhibiting Activin on ti...