Design, Synthesis, and Anti-Melanogenic Activity of 2-Mercaptomethylbenzo[<i>d</i>]imidazole Derivatives Serving as Tyrosinase Inhibitors: An In Silico, In Vitro, and In Vivo Exploration

• Main Authors: Hee Jin Jung (Author), Hyeon Seo Park (Author), Hye Jin Kim (Author), Hye Soo Park (Author), Yujin Park (Author), Pusoon Chun (Author), Hae Young Chung (Author), Hyung Ryong Moon (Author)
• Format: Book
• Published: MDPI AG, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

2-Mercaptomethylbenzo[<i>d</i>]imidazole (2-MMBI) derivatives were designed and synthesized as tyrosinase (TYR) chelators using 2-mercaptomethylimidazole scaffolds. Seven of the ten 2-MMBI derivatives exhibited stronger inhibition of mushroom TYR activity than kojic acid. Their ability t...