Design, Synthesis, and Anti-Melanogenic Activity of 2-Mercaptomethylbenzo[<i>d</i>]imidazole Derivatives Serving as Tyrosinase Inhibitors: An In Silico, In Vitro, and In Vivo Exploration

• Hoofdauteurs: Hee Jin Jung (Auteur), Hyeon Seo Park (Auteur), Hye Jin Kim (Auteur), Hye Soo Park (Auteur), Yujin Park (Auteur), Pusoon Chun (Auteur), Hae Young Chung (Auteur), Hyung Ryong Moon (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2024-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

2-Mercaptomethylbenzo[<i>d</i>]imidazole (2-MMBI) derivatives were designed and synthesized as tyrosinase (TYR) chelators using 2-mercaptomethylimidazole scaffolds. Seven of the ten 2-MMBI derivatives exhibited stronger inhibition of mushroom TYR activity than kojic acid. Their ability t...