Preclinical Efficacy and Toxicity Analysis of the Pan-Histone Deacetylase Inhibitor Gossypol for the Therapy of Colorectal Cancer or Hepatocellular Carcinoma

• Main Authors: Mascha Mayer (Author), Alexander Berger (Author), Christian Leischner (Author), Olga Renner (Author), Markus Burkard (Author), Alexander Böcker (Author), Seema Noor (Author), Timo Weiland (Author), Thomas S. Weiss (Author), Christian Busch (Author), Ulrich M. Lauer (Author), Stephan C. Bischoff (Author), Sascha Venturelli (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gossypol, a sesquiterpenoid found in cotton seeds, exerts anticancer effects on several tumor entities due to inhibition of DNA synthesis and other mechanisms. In clinical oncology, histone deacetylase inhibitors (HDACi) are applied as anticancer compounds. In this study, we examined whether gossypo...