Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme

• Main Authors: Nada H. El-Dershaby (Author), Soad A. El-Hawash (Author), Shaymaa E. Kassab (Author), Hoda G. Dabees (Author), Ahmed E. Abdel Moneim (Author), Ibrahim A. Abdel Wahab (Author), Mohammad M. Abd-Alhaseeb (Author), Mostafa M. M. El-Miligy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new series of co-drugs was designed based on hybridising the dihydropteroate synthase (DHPS) inhibitor sulphonamide scaffold with the COX-2 inhibitor salicylamide pharmacophore through biodegradable linkage to achieve compounds with synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme to...