Hydrotropic solubilization of lipophilic drugs for oral delivery: The effects of urea and nicotinamide on carbamazepine solubility-permeability interplay

• Main Authors: Avital Beig (Author), David Lindley (Author), Jonathan Miller (Author), Riad Agbaria (Author), Arik Dahan (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2016-10-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Hydrotropy refers to increasing the water solubility of otherwise poorly soluble compound by the presence of small organic molecules. While it can certainly increase the apparent solubility of a lipophilic drug, the effect of hydrotropy on the drugs' permeation through the intestinal membrane h...